Ankylosing Spondylitis Causes: Why It Happens in Men & Women

Updated: September 2, 2025
Authored by: Dr Batra's®

Medically reviewed by

TEJAL AJMERA PATEL
28+ Years of experience Dermatology, Hair Specialist, Oncology, Pediatrics, Skin Specialist

Ankylosing spondylitis (AS) is a chronic autoimmune disorder that primarily affects the spine and sacroiliac joints. Persistent inflammation in these areas can gradually cause the fusion of vertebrae, leading to significant stiffness, reduced mobility, and, in severe cases, a hunched posture.

This condition usually begins in early adulthood and can affect both men and women, though in different ways. A strong genetic link exists, especially for those carrying the HLA-B27 gene, which significantly increases the risk of developing AS, though it does not guarantee it. Understanding these root causes is the foundation of long-term healing. At Dr Batra's®, our homeopathic treatments aim to restore immune balance, relieve symptoms, and prevent future complications.

Most Common Causes of Ankylosing Spondylitis

Genetic Factor: Individuals with the HLA-B27 gene have a significantly higher risk. However, not everyone with this gene develops AS.
Immune System Dysfunction: The immune system mistakenly attacks healthy tissues, especially around joints and spine.
Family History: AS is more likely if you have a parent or sibling with the condition.
Infections: Certain bacterial infections may trigger an autoimmune response in individuals who are genetically predisposed to such responses.
Environmental Triggers: Factors like smoking, stress, and a sedentary lifestyle can increase inflammation and flare-ups.

Insight from a Global Study

A study in the International Journal of Clinical Rheumatology highlights that complete care works best for ankylosing spondylitis. Homeopathy supports this by gently reducing pain, controlling inflammation, and improving spine flexibility without side effects for long-term relief and better daily comfort.

Gender Differences in Causes

In Men:

Earlier onset of severe symptoms
Higher levels of spinal fusion
Stronger genetic link (HLA-B27)

In Women:

Milder, more peripheral joint symptoms
Delayed diagnosis due to non-specific signs
Greater association with hormonal changes

Warning Signs to Watch Out For

Chronic back pain, especially in the morning
Stiffness after rest
Fatigue and poor posture
Unexplained eye inflammation
Difficulty breathing due to chest stiffness

Dr Batra’s^® pro tip:

Stay active with daily stretches, maintain good posture, and incorporate anti-inflammatory foods like turmeric, leafy greens, berries, and walnuts into your diet to help ease stiffness. Homeopathy adds gentle, long-term relief by targeting the root cause of ankylosing spondylitis without side effects.

Tips to Reduce Risk

Regular movement and stretching
Anti-inflammatory diet rich in omega-3s and greens
Quit smoking and limit alcohol
Practice mindfulness or yoga to reduce stress
Get screened if you have a family history

Treat Ankylosing Spondylitis from the Root

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How Homeopathy Helps With Root Causes

Balances the immune system without suppressing symptoms
Personalised remedies based on emotional and physical profile
Safe for long-term use without side effects
Addresses genetic and environmental triggers

Dr Batra's® Personalised Homeopathy Approach

Tailored remedies for each stage of AS
Supportive care to ease stiffness, pain, and fatigue
Monitored progress using scientific assessment tools
Suitable alongside conventional treatments

Ankylosing Spondylitis: Homeopathy vs Allopathy (Conventional)

Aspect	Homeopathy	Allopathy (Conventional)
Safe for long-term use
Non–habit-forming
Suitable for chronic management
Risk of drug interactions
Need for regular lab monitoring
Rebound or withdrawal symptoms
Impact on gut microbiome

Find relief from stiffness with safe, personalised treatment

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Conclusion

Early AS detection, especially in HLA-B27 carriers, is crucial for slowing disease progression.
Homeopathy offers a root‑cause approach, easing pain and stiffness by balancing immunity.
Combining personalised remedies with exercise, diet, and stress management yields the best outcomes.
Dr Batra’s® personalised care ensures safe, long‑term relief and improved spinal health.

References

FAQs

The exact cause remains unclear, but it is closely associated with a genetic marker called HLA-B27. Immune system imbalance, environmental triggers like infections, and inflammation may also contribute to the development and progression of ankylosing spondylitis in susceptible individuals.

Yes. Genetics play a significant role, especially in individuals who carry the HLA-B27 gene. While not everyone with this gene develops the condition, it increases the risk. A family history of autoimmune disorders also contributes to higher susceptibility.

Absolutely. Poor posture, smoking, physical inactivity, and high stress levels can aggravate ankylosing spondylitis symptoms. Regular exercise, proper ergonomics, and stress management techniques can help reduce flare-ups and improve quality of life for those affected.

Yes. Men often experience classic lower back and spinal stiffness, while women are more likely to have pain in peripheral joints like the hips or knees. Due to subtle symptoms, women may be diagnosed later or misdiagnosed initially.

Yes. Research suggests that gastrointestinal infections or imbalances in gut microbiota may trigger immune responses in genetically predisposed individuals. This connection between gut health and immune activity is believed to play a role in disease onset or flares.